Chronic cancer has a long incubation period. Myeloproliferative neoplasms (MPN) are a form of blood cancer that can be managed by some individuals with treatment and long periods of watchful waiting for others. However, in a tiny number of patients, the slower-moving condition may develop into secondary acute myeloid leukaemia, an aggressive cancer with limited curative therapies. About how this change occurs, little is known. The findings of the research was published in the journal Nature Cancer.