About 1 out of every 100 students in American public schools has autism. A subset of these students also have academic gifts and talents in a broad range of areas, including math, science, technology, the humanities and the arts. These students are often referred to as “twice exceptional.” To learn more about this population, we conducted research with three groups: twice-exceptional autistic college students, their parents and college staff who work with them. The students were all enrolled in or recent graduates of competitive and very competitive colleges, including Ivy League institutions. We identified several strategies that can help these students transition to and succeed in college.