Intermittent fasting has become a hot topic in the wellness industry as numerous laboratory studies have shown the health benefits of time-restricted eating, including increased life span. However, exactly how it affects the body on the molecular level, and how those changes interact across multiple organ systems, has not been well understood. Now, Salk scientists show in mice how time-restricted eating influences gene expression across more than 22 regions of the body and brain. Gene expression is the process through which genes are activated and responds to their environment by creating proteins.